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A diminished response to killed vaccines is likely and such a response to hepatitis B vaccine has been observed among patients treated with a combination of azathioprine and corticosteroids.

Using Imuran for a long time may increase your risk of skin cancer and lymphomaLymphoma is a cancer that affects your immune cells.

There are potential hazards in the use of ImuranIt should be prescribed only if the patient can be adequately monitored for toxic effects throughout the duration of therapy.

TPMT TESTING CANNOT SUBSTITUTE FOR COMPLETE BLOOD COUNTCBCMONITORING IN PATIENTS RECEIVING IMURANTPMT genotyping or phenotyping can be used to identify patients with absent or reduced TPMT activityPatients with low or absent TPMT activity are at an increased risk of developing severelife-threatening myelotoxicity from IMURAN if conventional doses are givenPhysicians may consider alternative therapies for patients who have low or absent TPMT activityhomozygous for non-functional allelesIMURAN should be administered with caution to patients having one non-functional alleleheterozygouswho are at risk for reduced TPMT activity that may lead to toxicity if conventional doses are givenDosage reduction is recommended in patients with reduced TPMT activityEarly drug discontinuation may be considered in patients with abnormal CBC results that do not respond to dose reduction.

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