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Geriatric patients are at increased risk for developing severe tendon disorders including tendon rupture when being treated with a fluoroquinolone such as NOROXIN. This risk is further increased in patients receiving concomitant corticosteroid therapy. Tendinitis or tendon rupture can involve the Achilles.hand.shoulder.or other tendon sites and can occur during or after completion of therapy. cases occurring up to several months after fluoroquinolone treatment have been reported. Caution should be noroxin treatment when prescribing NOROXIN to elderly patients.especially those on corticosteroids. Patients should be informed of this potential side effect and advised noroxin treatment discontinue NOROXIN and contact their healthcare provider if any symptoms of tendinitis or tendon rupture occur (see BOXED WARNING . WARNINGS . and ADVERSE REACTIONS .Post-Marketing ).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication noroxin treatment not have serious side effects.

inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase.inhibition of the relaxation of supercoiled DNA.promotion of double-stranded DNA breakage.

A very serious allergic reaction to this drug is rare. However.get medical help right away if you notice any symptoms of a serious allergic reaction.including. rash.itching/swelling (especially of the face/tongue/throat).severe dizziness.trouble breathing.

Norfloxacin should be separated from aluminum and magnesium containing antacids.sucralfate (Carafate).and multivitamins because they can lower absorption of norfloxacin and reduce its effectiveness. They should be administered 2 hours before norfloxacin.

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